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As shown in Scheme 6, Heck-type cross-couplings can be performed by suspending a halogenated tetracycline compound ( eg, 7-iodosancycline, 6A) and an appropriate palladium or other transition metal catalyst ( eg, Pd(OAc) 2 and CuI) in an appropriate solvent ( eg, degassed acetonitrile)! Featured are sensational fall creations from October 1921! The insoluble material was filtered and the filterate was dried to yield the crude product.
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